Vitamin C Can Alter Lead-Induced Passive Avoidance Learning Impairment in Rats

Introduction: Lead (Pb) is a neurotoxin that its different effects on the central nervous system&nbsp;are well-known. Previous studies have reported the potent effects of vitamin C on memory.The present study was undertaken to evaluate the protective effects of vitamin C against leadinduced&nbsp;amnesia. Methods: Male Wistar rats were divided into 4 groups: the control (saline), negative control&nbsp;(lead), positive control (Vitamin C, 150 mg/kg), and experimental (Lead+Vitamin C). To&nbsp;induce lead toxicity, the rats received water containing 0.2% Pb instead of regular water for 1&nbsp;month. Passive avoidance learning was assessed by Shuttle Box 2 months later. Retention was&nbsp;tested 24 hours after training.&nbsp; Results: The results showed that lead causes impairment in acquisition and retrieval processes&nbsp;of passive avoidance learning and memory. However, vitamin C administration reinforced&nbsp;passive avoidance learning and memory. All results were significant (P<0.001). Conclusion: Vitamin C administration in rats counteracts the negative effect of lead on spatial&nbsp;learning and memory.